Pharmacokinetics/Pharmacodynamics (PK/PD) of Antimicrobials and Novel Agents
A workshop for graduate students, pharmacy students, and postdocs
Jacob K. McPherson
University of Houston College of Pharmacy
October 21, 2025
Background Clinical Microbiology
You already know:
Minimum Inhibitory Concentrations (MIC)1
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You already know:
Minimum Bactericidal Concentrations (MBC)2
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Only ‘Free’ Antibiotics are Microbiologically Active
Commonly used parameters
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PK/PD Indices Predict Efficacy
Commonly used parameters
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Pharmacokinetics (PK) 101
Fundamentals of Biopharmaceutics
Shargel and Yu’s Biopharmaceutics and Pharmacokinetics, 8th Edition, 2022
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Drug distribution and protein binding
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Physiology of drug Elimination
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Introduction to PK/PD models
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One-compartment Open Model: IV bolus
Pharmacokineitcs of Drug Elimination and Clearance
Pharmacokinetics of Drug Absorption
Multiple-dosage regimens
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Nonlinear pharmacokinetics
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Empiric Models, Mechanistic Models, Statistical Moments, and Non-compartmental Models
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Relationship between Pharmacokinetics and Pharmacodynamics
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Application of Pharmacokinetics to Clinical Situations
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Application of Pharmacokinetics and Pharmacodynamics to Aging, Obese, and Pediatric Patients
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Dose Adjustment in Renal and Hepatic Diseases
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Pharmacokinetics and Pharmacodynamics in Clinical Drug Product Development
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Pre-clinical Models of Infection
The in vitro Hollow-Fiber Infection Model (HFIM)
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The in vivo Animal Models of Infection
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Six Clinical Cases
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Analysis of in vitro HFIM data
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Six Clinical Cases
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Analysis via PopPK
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